Explore how trial intent influences design decisions and where a study sits on the explanatory–pragmatic continuum. The module introduces PRECIS-2 and considers how choices about participants, settings, delivery, follow-up, and outcomes affect both internal validity and real-world relevance.
Key ideas
- How a trial's purpose shapes its design choices
- The distinction between efficacy and effectiveness questions
- How eligibility, setting, delivery, follow-up, and outcomes affect applicability
- How PRECIS-2 supports deliberate, fit-for-purpose trial design